St. John's wort might also increase your sensitivity to sunlight. Linde K, Ramirez G, Mulrow CD, et al. Evaluation of chemical stability of St. John's wort commercial extract and some preparations. The American College of Physicians-American Society of Internal Medicine guidelines show that St. John's wort can be considered an option along with prescription medications for short-term treatment of mild depression. Roots I, Johne A, Schmider J, Brockmoller J, et al. View abstract. St. John's wort is available as a supplement in teas, tablets, liquids and topical preparations. View abstract. Consult Pharm. View abstract. 2004;72(6):330-343. Arch Surg 2002;137:316-9. Published: September, 2005. 2005;15(2):293-301. Clin Pharmacol Ther 2000;67:130, abstract PII-64. Medications for HIV/AIDS (Protease Inhibitors) interacts with ST. JOHN'S WORT. St. John's wort can increase how quickly the body breaks down tacrolimus. Obstet Gynecol 2006;107(2 Pt 1):247-55. Kobak KA, Taylor LV, Bystritsky A, et al. View abstract. View abstract. By decreasing how fast the body gets rid of some medications for pain, St. John's wort might increase the effects and side effects of some medications for pain. Pharmacopsychiatry 1997;30 Suppl 2:108-112. O'Breasail AM, Argouarch S. Hypomania and St John's wort. Luminescence. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others. Grube, B., Walper, A., and Wheatley, D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Role of flavonoids in controlling the phototoxicity of Hypericum perforatum extracts. View abstract. Anaesthesia 2000;55(1):101-102. Biochem Pharmacol 10-15-2001;62(8):1059-1070. Pain 2000;91:361-5. Early research shows that in people who do not respond to a prescription blood thinner medication called clopidogrel or Plavix and aspirin, taking St. John's wort three times daily for 2 weeks after a procedure to clear blocked arteries might improve outcomes of the procedure. de Maat M, Hoetelmans R, Mathot R, et al. Taylor LH, Kobak KA. The body breaks down some medications for pain to get rid of them. Taking St. John's wort along with alprazolam (Xanax) might decrease the effectiveness of alprazolam (Xanax). Mania associated with St. John's wort. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Some early research suggests that St. John's wort might help reduce PMS symptoms, including sleeping problems, confusion, crying, headache, tiredness, food cravings and swelling, by as much as 50% in some women. Hypericum Depression Trial Study Group. Determining hyperforin and hypericin content in eight brands of St. John's wort. Clin Pharmacol Ther 2004;76:323-9. Harrer G, Schmidt U, Kuhn U, Biller A. View abstract. View abstract. St. John's wort: Three cases of possible mania induction. What can we help you find? Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. St. John's wort might decrease the effectiveness of sedative medications. View abstract. View abstract. Berlanda, J., Kiesslich, T., Engelhardt, V., Krammer, B., and Plaetzer, K. Comparative in vitro study on the characteristics of different photosensitizers employed in PDT. View abstract. Int.J.Gynaecol.Obstet. Yechiam E, Ben-Eliezer D, Ashby NJS, Bar-Shaked M. The acute effect of Hypericum perforatum on short-term memory in healthy adults. Taking St. John's wort along with some medications that are broken down by the liver can decrease the effectiveness of your medication. 2009;16(1):156-163. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others. Climacteric 2014;17:325-335. A report of 3 males aged 14-16 with ADHD showed that taking St. John's wort daily for 4 weeks might improve attention and activity. Xenobiotica 2010;40(4):275-81. St. John's wort (Hypericum perforatum) is a flowering shrub native to Europe.

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